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Abstract We discuss quantum position verification (QPV) protocols in which the verifiers create and send single-qubit states to the prover. QPV protocols using single-qubit states are known to be insecure against adversaries that share a small number of entangled qubits. We introduce QPV protocols that are practically secure: they only require single-qubit states from each of the verifiers, yet their security is broken if the adversaries sharing an impractically large number of entangled qubits employ teleportation-based attacks. These protocols are a modification of known QPV protocols in which we include a classical random oracle without altering the amount of quantum resources needed by the verifiers. We present a cheating strategy that requires a number of entangled qubits shared among the adversaries that grows exponentially with the size of the classical input of the random oracle. 

Abstract Damaged or mismatched DNA bases result in the formation of physical defects in double-stranded DNA. In vivo, defects in DNA must be rapidly and efficiently repaired to maintain cellular function and integrity. Defects can also alter the mechanical response of DNA to bending and twisting constraints, both of which are important in defining the mechanics of DNA supercoiling. Here, we use coarse-grained molecular dynamics (MD) simulation and supporting statistical-mechanical theory to study the effect of mismatched base pairs on DNA supercoiling. Our simulations show that plectoneme pinning at the mismatch site is deterministic under conditions of relatively high force (>2 pN) and high salt concentration (>0.5 M NaCl). Under physiologically relevant conditions of lower force (0.3 pN) and lower salt concentration (0.2 M NaCl), we find that plectoneme pinning becomes probabilistic and the pinning probability increases with the mismatch size. These findings are in line with experimental observations. The simulation framework, validated with experimental results and supported by the theoretical predictions, provides a way to study the effect of defects on DNA supercoiling and the dynamics of supercoiling in molecular detail.